Dissecting immunity by germline mutagenesis
نویسندگان
چکیده
منابع مشابه
Dissecting mammalian immunity through mutation
Although mutation and natural selection have given rise to our immune system, a well-placed mutation can also cripple it, and within an expanding population we are recognizing more and more cases of single-gene mutations that compromise immunity. These mutations are an ideal tool for understanding human immunology, and there are more ways than ever to measure their physiological effects. There ...
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Sleeping Beauty is a synthetic "cut-and-paste" transposon of the Tc1/mariner class. The Sleeping Beauty transposase (SB) was constructed on the basis of a consensus sequence obtained from an alignment of 12 remnant elements cloned from the genomes of eight different fish species. Transposition of Sleeping Beauty elements has been observed in cultured cells, hepatocytes of adult mice, one-cell m...
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Arikuni Uchimura*, Yuichiro Hara†, Yoichi Gondo and Yusaku Nakabeppu Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minami, Chuo-ku, Kobe, Hyogo 650-0047, Japan Mutagenesis and Genomics Team, RIKEN BioResource Center, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan Research Center fo...
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Functional studies will facilitate characterization of role and essentiality of newly available genome sequences of the human schistosomes, Schistosoma mansoni, S. japonicum and S. haematobium. To develop transgenesis as a functional approach for these pathogens, we previously demonstrated that pseudotyped murine leukemia virus (MLV) can transduce schistosomes leading to chromosomal integration...
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The immune and inflammatory responses are extraordinarily complex, involving the dynamic interaction of a wide array of tissues, cells, and molecules. Traditional approaches are by and large reductionist, shying away from complexity, but providing detailed knowledge of circumscribed physiologic, cellular and molecular entities. The sequencing of the human genome, in concert with emerging genomi...
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ژورنال
عنوان ژورنال: Immunology
سال: 2012
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2012.03613.x